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Are liposomes harmful?

by Viet Trinh on February 14, 2022

Liposomes are not harmful . Liposomes only describe the structure of very small spheres. These beads consist of a bilayer membrane. The membrane-forming molecules consist of a hydrophilic/lipophobic and a hydrophobic/lipophilic layer.[1] The hydrophobic parts of the molecules face each other so that they have little contact with the aqueous phase, whereas the hydrophilic parts of the molecules face the aqueous phase inside and outside the liposome:

Another article wrote in detail " What liposomes are " and what the bioavailability is all about. This article is about questioning whether liposomes are harmful. Due to the spherical shape, the interior is very receptive to absorbing a variety of lipophilic substances. And this is where "harmful" ingredients can now be stored. The greatest challenge is to use questionable substances in production that can cause allergic reactions.[2] With some medicines, of course, excipients are necessary so that the substance can be transported. In the field of dietary supplements, too, some manufacturers tend to use questionable substances. But other than that, can there be any other concerns? no The liposomal formulation can protect sensitive substances from possible metabolism/enzymatic degradation. In addition, liposomes can reduce the plasma half-life so that the substances stay in the blood longer. An overdose can be the result. So it's a matter of interpretation. Do you want to have the substance contained in the liposomes in your blood for a long time or not? In many cases that may be the case: for example, water-soluble vitamins. The water-soluble vitamins include the B vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 ​​(pyridoxine), B8 (biotin), B9 (folic acid), B12 (cobalamin). And of course the well-known vitamin C. The body cannot store water-soluble vitamins and excretes them again. It therefore makes sense to make these available throughout the day.


  1. Shaheen, SM, et al. Liposomes as a carrier for advanced drug delivery. Pak J Biol Sci. 2006, 9(6): 1181-1191.
  2. Nakhaei P, Margiana R, Bokov DO, Abdelbasset WK, Kouhbanani MAJ et al. (2021): Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol. Front. Bioeng. biotech. https://www.vinplus.de/wp-content/uploads/2022/01/fbioe-09-705886.pdf

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